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Differential Diagnosis for Specific Signs and Symptoms
Dec 21, 2024
•
Mark Morgan
categories:
differential diagnosis
This is a tool to help build a differential diagnosis.
Differential Diagnosis for Specific Signs or Symptoms
Signs or Symptoms -->
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Abdominal and pelvic pain
Abnormal uterine bleeding
Back pain
Chest pain
Cough
Cough, dyspnea (infant, newborn)
Crying infant (Inconsolable)
Delirium
Dementia, memory loss
Diarrhea
Dysphagia
Dyspnea, tachypnea
Ear pain, otalgia
Edema, leg
Facial flushing
Facial pain
Fever (acute, uncertain source)
Flank pain
Genital skin lesion, genital ulcer
Headache
Hearing loss (deafness)
Hematuria
Hypotension, shock
Leg pain, bone pain, extremity pain
Limp in child
Lymphadenopathy
Mental status, acute change (coma, lethargy)
Muscle cramps
Nausea, vomiting
Numbness, sensory loss
Pruritus
Rash, generalized
Red eye
Scrotal pain
Seizure
Shoulder pain
Sinus tachycardia
Syncope
Tinnitus
Tremor
Urinary symptoms (dysuria, frequency, urgency)
Vertigo
Weakness, fatigue, malaise, vague symptoms
Weight loss
DIFFERENTIAL DIAGNOSIS
Peptic gastritis, esophagitis
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Viral gastroenteritis
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Constipation
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*Psychiatric (depression, sexual abuse)
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Irritable bowel syndrome
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♠Diverticulitis
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♠Pancreatitis
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♠Gallbladder disease
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♠Bowel obstruction, partial small bowel obstruction
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♠*Pregnancy complication, ectopic pregnancy
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Mesenteric adenitis
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♠*Appendicitis
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♠*Myocardial infarction
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♠Kidney stone
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♠Pelvic inflammatory disease
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♠Ovarian cyst, ovarian torsion, endometritis
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Endometriosis
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Abdominal wall pain (trigger point pain)
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Herpes zoster
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Celiac disease
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♠Hepatitis, hepatic abscess
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♠*Pneumonia, empyema
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Mittleschmerz
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♠*Intraabdominal tumor
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Giardia
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♠*Diabetic ketoacidosis
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♠*Aortic dissection, ruptured aneurysm
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♠Mesenteric ischemia, infarction
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♠Hernia
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♠Perforated viscus, peritonitis
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Food poisoning
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Inflammatory bowel disease
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♠Sickle cell crisis
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♠Lead poisoning
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♠Leukemia
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♠Meckel's diverticulitis
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♠Fitz-Hugh-Curtis syndrome
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Familial Mediterranean Fever
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Porphyria
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Periarteritis nodosa
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Black Widow Spider bite
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Anovulatory bleeding, polycystic ovary syndrome
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Menorrhagia
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Contraceptive related abnormal bleeding (oral, depomedroxyprogesterone, intrauterine device, progestin implant)
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♠Ectopic pregnancy
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♠Intrauterine pregnancy complication
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♠Endometrial cancer, hyperplasia
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Polyps
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Fibroids
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♠Endometritis
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Hyperprolactinemia
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Thyroid disease
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Drugs (anticoagulants, psychotropics)
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Normal variation (postmenarchal, perimenopausal, premenstrual spotting, postmenstrual spotting, midcycle ovulatory bleeding)
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Coagulopathy (von Willebrand)
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Organ failure (late manifestation: kidney failure, liver failure)
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♠Depression, agitated depression, bipolar disorder
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Anxiety (situational, generalized anxiety disorder)
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Panic disorder
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Alcohol
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♠Hypoglycemia
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Medications
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♠Thyroid disorder
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Paraneoplastic syndrome
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♠Pulmonary embolus
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♠Hypoxemia
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♠Pheochromocytoma
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Musculoskeletal, nonspecific
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Herniated disk
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Spinal stenosis
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♠Gall bladder disease
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Compression fracture
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♠Pyelonephritis, kidney stone
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♠Pancreatitis, pancreatic carcinoma
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♠*Pulmonary embolus
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♠*Pneumonia
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Psychiatric
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Herpes zoster
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Vitamin D deficiency
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♠Polymyalgia rheumatica
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Prostatitis
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♠*Abdominal or thoracic aortic aneurysm
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♠Metastatic tumor
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♠Abdominal tumor
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♠Penetrating ulcer
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♠Infection (diskitis, osteomyelitis, spinal abscess)
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Chest wall pain
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GERD
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Pleurisy, pleuritis
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*Psychiatric
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♠*Coronary disease (myocardial infarction, angina)
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♠*Pulmonary embolus
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Herpes zoster
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♠*Pneumonia, bronchitis
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♠Pneumothorax
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Esophageal spasm
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Pericarditis, myocarditis
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♠Aortic stenosis
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♠*Dissecting aortic aneurysm
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♠*Tumor
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♠Esophageal rupture
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♠*Spinal cord compression
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Viral upper respiratory infection
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Postnasal drip
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Postinfectious, postviral cough
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Bronchitis
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Asthma, chronic obstructive pulmonary disease
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Gastroesophageal reflux
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*Drugs (angiotensin converting enzyme inhibitors, beta blockers, amiodarone)
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♠*Pneumonia
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External or middle ear disease
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Aspiration, recurrent
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♠*Pulmonary embolus
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♠Pertussis
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Psychogenic
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♠*Heart failure
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♠*Tumor
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♠Epiglottitis
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♠Acute histoplasmosis
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Interstitial lung disease
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Bronchiectasis
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♠Sarcoidosis
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♠*Tuberculosis
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♠Cystic fibrosis
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♠Laryngeal tumor
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♠Mitral stenosis
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♠Foreign body
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Viral upper respiratory infection
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Respiratory syncytial virus (RSV)
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Transient tachypnea
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♠Sepsis
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Infant respiratory distress syndrome
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Metapneumovirus
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♠Pneumothorax
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♠Pneumonia
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Asthma
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♠Heart disease
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Idiopathic
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Colic
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♠Infections (otitis media, viral illness, urinary tract infection,
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herpes stomatitis)
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♠Fracture
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Corneal abrasion
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Constipation
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Immunization reaction
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♠Hair tourniquet syndrome
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♠*Drugs
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*Psychiatric disorders
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♠Alcohol
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♠*Anemia
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♠*Glucose disturbances
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♠Serotonin syndrome
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♠Trauma
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♠Head injury
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♠*Myocardial infarction
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♠Carbon monoxide
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♠Sepsis
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♠Electrolyte disturbance, Na, Ca, Mg, P
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♠Thyroid disease
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♠Hypoxia
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♠Hypertensive encephalopathy
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♠CNS infections
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♠Brain mass
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♠Hypothermia
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♠Hyperthermia
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♠B12 deficiency
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♠Folate deficiency
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♠Thiamine deficiency
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♠Liver failure
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♠*Heart failure
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♠Renal failure
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Burns
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Postpartum psychosis
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♠Adrenal disease
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♠Porphyria
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♠Nonconvulsive status epilepticus
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Alzheimer disease
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♠Pseudodementia (depression)
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Mild cognitive impairment
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♠Medications (antihistamines)
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Alcohol
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Vascular dementia
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Dementia with Lewy bodies
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Parkinson disease
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♠Vitamin B12 deficiency
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♠Hypothyroidism
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♠Delirium
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♠Anoxia
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♠Hypoglycemia
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AAFP
♠Midbrain stroke
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CLINIBORG
*
Pub Med
*
Medline Plus
*
AAFP
Multiple sclerosis
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CLINIBORG
*
Pub Med
*
Medline Plus
*
AAFP
♠Serotonin syndrome
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*
Pub Med
*
Medline Plus
*
AAFP
♠Carcinoid
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*
Pub Med
*
Medline Plus
*
AAFP
♠Wilson's disease
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*
Pub Med
*
Medline Plus
*
AAFP
♠Pheochromocytoma
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*
Pub Med
*
Medline Plus
*
AAFP
♠Urinary tract infection
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CLINIBORG
*
Pub Med
*
Medline Plus
*
AAFP
♠Urethritis (chlamydia, gonococcus, unknown)
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CLINIBORG
*
Pub Med
*
Medline Plus
*
AAFP
Vaginitis
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*
Pub Med
*
Medline Plus
*
AAFP
Atrophic vaginitis
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Pub Med
*
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*
AAFP
Genital herpes
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*
Pub Med
*
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*
AAFP
Interstitial cystitis
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*
Pub Med
*
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*
AAFP
Irritant urethritis
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*
Pub Med
*
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*
AAFP
Daytime frequency of childhood syndrome
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*
Pub Med
*
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*
AAFP
♠Prostatitis
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*
Pub Med
*
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*
AAFP
Reactive arthritis (Reiter's syndrome)
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*
Pub Med
*
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*
AAFP
Hypercalciuria
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*
Pub Med
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*
AAFP
Psychiatric
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*
Pub Med
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AAFP
Benign Positional Vertigo
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*
Pub Med
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*
AAFP
Meniere's disease
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*
Pub Med
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*
AAFP
Vestibular neuronitis, acute labyrinthitis
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*
Pub Med
*
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*
AAFP
♠Acoustic neuroma
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*
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*
AAFP
Post-concussion syndrome
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*
Pub Med
*
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*
AAFP
♠Otitis media
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*
Pub Med
*
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*
AAFP
Barotrauma, ruptured oval window, perilymph leak
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*
Pub Med
*
Medline Plus
*
AAFP
Migrainous vertigo
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*
Pub Med
*
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*
AAFP
Otosclerosis
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*
Pub Med
*
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*
AAFP
♠Vertebral artery dissection
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*
Pub Med
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*
AAFP
♠*Brain stem stroke
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*
Pub Med
*
Medline Plus
*
AAFP
Psychiatric
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*
Pub Med
*
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*
AAFP
♠Drugs (gentamicin, furosemide)
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*
Pub Med
*
Medline Plus
*
AAFP
Obstructive sleep apnea
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*
Pub Med
*
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*
AAFP
♠Depression, anxiety
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*
Pub Med
*
Medline Plus
*
AAFP
Deconditioning
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*
Pub Med
*
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*
AAFP
*Drugs (beta blocker, clonidine, alcohol)
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*
Pub Med
*
Medline Plus
*
AAFP
Chronic fatigue syndrome, fibromyalgia
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*
Pub Med
*
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*
AAFP
♠*Infections, infectious mononucleosis, hepatitis, pneumonia
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*
Pub Med
*
Medline Plus
*
AAFP
♠Pregnancy
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*
Pub Med
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AAFP
♠*Anemia
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*
Pub Med
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*
AAFP
Vitamin D deficiency
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*
Pub Med
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*
AAFP
♠Hypothyroidism, hyperthyroidism
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*
Pub Med
*
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*
AAFP
♠Hypokalemia, hyponatremia
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*
Pub Med
*
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*
AAFP
♠*Myocardial infarction
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*
Pub Med
*
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*
AAFP
♠Celiac disease
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*
Pub Med
*
Medline Plus
*
AAFP
♠Disturbance of calcium, phosphorus, magnesium
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*
Pub Med
*
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*
AAFP
♠Polymyalgia rheumatica/Temporal arteritis
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Pub Med
*
Medline Plus
*
AAFP
Parkinson disease
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AAFP
Hypogonadism
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AAFP
Myasthenia gravis
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AAFP
♠*Heart failure, myocarditis
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*
Pub Med
*
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*
AAFP
Pulmonary, hepatic, renal failure
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*
Pub Med
*
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*
AAFP
Multiple sclerosis
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*
Pub Med
*
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*
AAFP
♠Adrenal insufficiency, Addison’s disease
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*
Pub Med
*
Medline Plus
*
AAFP
B12 deficiency
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*
Pub Med
*
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*
AAFP
♠Botulism
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*
Pub Med
*
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*
AAFP
Black widow spider bite
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*
Pub Med
*
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*
AAFP
♠Depression
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*
Pub Med
*
Medline Plus
*
AAFP
Chronic obstructive pulmonary disease
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*
Pub Med
*
Medline Plus
*
AAFP
Drugs
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*
Pub Med
*
Medline Plus
*
AAFP
Dementia
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*
Pub Med
*
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AAFP
♠*Malignancy
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Pub Med
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*
AAFP
Eating disorder
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*
Pub Med
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*
AAFP
Anorexia of aging
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*
Pub Med
*
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*
AAFP
*Diabetes
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*
Pub Med
*
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*
AAFP
♠Hyperthyroidism
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*
Pub Med
*
Medline Plus
*
AAFP
♠HIV
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*
Pub Med
*
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AAFP
♠*Tuberculosis
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*
Pub Med
*
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*
AAFP
♠Adrenal insufficiency
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*
Pub Med
*
Medline Plus
*
AAFP
♠Uremia
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*
Pub Med
*
Medline Plus
*
AAFP
Liver disease
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*
Pub Med
*
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AAFP
Intestinal parasites
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*
Pub Med
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AAFP
Malabsorption
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*
Pub Med
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AAFP
Inflammatory bowel disease
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*
Pub Med
*
Medline Plus
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AAFP
(♠) <-- must-not-miss diagnoses
(*) <-- commonly missed diagnoses[/conditional]
display/hide references
reference:
Ely JW, Graber ML, Croskerry P. Checklists to reduce diagnostic errors. Acad Med. 2011 Mar;86(3):307-13.
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